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Cd82tm1.1Xaz
Targeted Allele Detail
Nomenclature
Symbol: Cd82tm1.1Xaz
Name: CD82 antigen; targeted mutation 1.1, Xin A Zhang
MGI ID: MGI:5790985
Gene: Cd82  Location: Chr2:93419102-93462950 bp, - strand  Genetic Position: Chr2, 51.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234155
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette with a 5 loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the selection cassette and exons 5 and 6. Western blot analysis confirmed the absence of protein expression in the spleen, T cells, B cells and dendritic cells. (J:234155)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd82 Mutation:  4 strains or lines available
References
Original:  J:234155 Wei Q, et al., CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation. 2014 Oct 21;130(17):1493-504
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory