Cdkl5^tm2.1Joez
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm2.1Joez
• Name: cyclin dependent kinase like 5; targeted mutation 2.1, Zhaolan Zhou
• MGI ID: MGI:5790794
• Synonyms: CDKL5 R59X
• Gene: Cdkl5 Location: ChrX:159567241-159777673 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm2.1Joez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276174
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting vector was designed to insert a FRT-flanked neomycin resistance (neo) cassette downstream of exon 5, and a single nucleotide change of C to T, leading to a nonsense mutation at arginine 59 (R59X). Flp-mediated recombination removed the neo cassette. (J:276174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 20 strains or lines available

References

• Original: J:276174 Tang S, et al., Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder. Nat Commun. 2019 Jun 14;10(1):2655
• All: 4 reference(s)