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Fubp1tm1.1Dlev
Targeted Allele Detail
Nomenclature
Symbol: Fubp1tm1.1Dlev
Name: far upstream element (FUSE) binding protein 1; targeted mutation 1.1, David Levens
MGI ID: MGI:5789037
Synonyms: Fubp1-
Gene: Fubp1  Location: Chr3:152210422-152236826 bp, + strand  Genetic Position: Chr3, 77.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229985
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted between exons 7 and 8 and a loxP and frt-flanked neomycin selection cassette was inserted between exons 13 and 14. After FLP and Cre-mediated recombination, a deletion of exons 8-13 was created, with a single loxP and a single frt site remaining at the deletion site. This deletion removes K homology (KH) motifs 2, 3 and the amino terminal half of KH4, yielding an allele that is incapable of expressing a protein that binds properly with single-strand nucleic acids. Immunoblot analysis confirmed the absence of protein expression in primary MEFs derived from E13.5 homozygous mutant embryos. (J:229985)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fubp1 Mutation:  47 strains or lines available
References
Original:  J:229985 Zhou W, et al., Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. Am J Pathol. 2016 Mar;186(3):701-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory