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QTL Variant Detail
QTL variant: Prdt6C3H/HeJ
Name: prion disease incubation time 6; C3H/HeJ
MGI ID: MGI:5789036
QTL: Prdt6  Location: Chr14:16430839-18038090 bp  Genetic Position: Chr14, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Inheritance:    Not Specified
The authors determined that the Prdt6 locus is driven by the presence of a bi-allelic split present among the eight inbred founder strains of the Northport HS stock: A= A/J, AKR/J, BALB/cJ, C57BL/6J; C= C3H/HeJ, CBA/J, DBA/2J, LP/J. We have created allele records for the strains A/J and C3H/HeJ to represent the "A" and "C" allele groups, respectively.

Mapping and Phenotype information for this QTL, its variants and associated markers


A locus on mouse Chromosome 14 was shown as displaying an association with prion disease susceptibility incubation as indicated using Northport heterogeneous stock (HS)animals.This HS stock was derived from semi-randomly mated parental inbred strains A/J,AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J LP/J. Strain distribution patterns of the aformentioned strains indicated that a QTL region containing Prdt6 was associated with Rarb (rs48898775 exon 3, Allele test p value = .0002) and Thrb (rs16822230 Exon 6,Allele test p-value = .0005)

Original:  J:167733 Grizenkova J, et al., The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse. PLoS One. 2010;5(12):e15019
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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