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Targeted Allele Detail
Symbol: Sgtatm1.1Drmcr
Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; targeted mutation 1.1, Dame Roma Mitchell Cancer Research
MGI ID: MGI:5788683
Gene: Sgta  Location: Chr10:81044075-81060181 bp, - strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:234007
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector was designed to insert a loxP upstream of exon 4 (containing the start codon), and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 5 gene. Cre-mediated recombination removed exons 4 through 5 and the neo cassette. Western blot and immunohistochemistry of prostrate and ovary confirmed that no protein was expressed in mutant mice. (J:234007)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sgta Mutation:  2 strains or lines available
Original:  J:234007 Philp LK, et al., Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice. Sci Rep. 2016;6:28950
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory