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Targeted Allele Detail
Symbol: Ppp3cctm1.1Osb
Name: protein phosphatase 3, catalytic subunit, gamma isoform; targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:5788175
Synonyms: Ppp3cctm1a(EUCOMM)Osb
Gene: Ppp3cc  Location: Chr14:70217865-70289471 bp, - strand  Genetic Position: Chr14, 36.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:226539
Parent Cell Line:  EGR-G101 (ES Cell)
Strain of Origin:  C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA IKMC vector (design ID:85228) inserted an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site and loxP site upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exon 3. Western blot analysis confirmed the absence of protein expression in the testis and sperm. (J:226539)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp3cc Mutation:  20 strains or lines available
Original:  J:226539 Miyata H, et al., Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. Science. 2015 Oct 23;350(6259):442-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory