Nkx2-5tm1.2Mwc
Targeted Allele Detail
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Symbol: |
Nkx2-5tm1.2Mwc |
Name: |
NK2 homeobox 5; targeted mutation 1.2, Mauro W Costa |
MGI ID: |
MGI:5788099 |
Synonyms: |
Nkx2-5delta |
Gene: |
Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
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Alliance: |
Nkx2-5tm1.2Mwc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:231297
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The targeting construct inserted a loxP site upstream of exon 1 and an FRT-flanked neomycin selection cassette and loxP site in the 3' UTR in exon 2. Subsequent flp-mediated recombination removed the neo cassette and cre-mediated recombination deleted exon 1 and most of exon 2, leaving the 3' end of the 3' UTR.
(J:231297)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nkx2-5 Mutation: |
21 strains or lines available
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Original: |
J:231297 Furtado MB, et al., A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels. Differentiation. 2016 Jan-Mar;91(1-3):29-41 |
All: |
1 reference(s) |
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