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Dpp4tm1(DPP4)Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Dpp4tm1(DPP4)Vlcg
Name: dipeptidylpeptidase 4; targeted mutation 1, Velocigene
MGI ID: MGI:5788094
Gene: Dpp4  Location: Chr2:62330073-62412231 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223728
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Dpp4tm1(DPP4)Vlcg expresses 1 gene
 
Mutation detailsExons 2 through 26, including the 3'UTR, of the human genomic sequence (from BAC RP11-68L22) replaced 79 kb of the corresponding mouse sequence. (J:223728)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  43 strains or lines available
References
Original:  J:223728 Pascal KE, et al., Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory