Dpp4^{tm1(DPP4)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Dpp4^{tm1(DPP4)Vlcg}
• Name: dipeptidylpeptidase 4; targeted mutation 1, Velocigene
• MGI ID: MGI:5788094
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^{tm1(DPP4)Vlcg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223728
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Dpp4^{tm1(DPP4)Vlcg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: Exons 2 through 26, including the 3'UTR, of the human genomic sequence (from BAC RP11-68L22) replaced 79 kb of the corresponding mouse sequence. (J:223728)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 73 strains or lines available

References

• Original: J:223728 Pascal KE, et al., Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43
• All: 5 reference(s)