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Cap2tm1e(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Cap2tm1e(EUCOMM)Wtsi
Name: CAP, adenylate cyclase-associated protein, 2 (yeast); targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID: MGI:5776537
Synonyms: Cap2gt
Gene: Cap2  Location: Chr13:46501903-46650281 bp, + strand  Genetic Position: Chr13, 23.83 cM
Mutation
origin
Mutant Cell Lines:  EPD0155_4_B07, EPD0155_4_D07
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 46530525 of Chromosome 13 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. This targeted allele has lost the 3' loxP site present in the tm1a allele. This mutation cannot be converted into a conditional allele. (J:155845)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cap2 Mutation:  6 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory