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Ido1tm1.1Mkks
Targeted Allele Detail
Nomenclature
Symbol: Ido1tm1.1Mkks
Name: indoleamine 2,3-dioxygenase 1; targeted mutation 1.1, Mark K Santillan
MGI ID: MGI:5775113
Gene: Ido1  Location: Chr8:24584133-24596952 bp, - strand  Genetic Position: Chr8, 12.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229059
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exons 2 through 10. Cre-mediate recombination removed the selection cassette. RT-PCR confirmed transcript expression below detectable limits in the spleen, heart, kidney, liver and lung. (J:229059)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ido1 Mutation:  19 strains or lines available
References
Original:  J:229059 Santillan MK, et al., Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep. 2015 Jan 1;3(1)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory