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Tg(Thy1-MAPT*L266V*G272V)13Ema
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT*L266V*G272V)13Ema
Name: transgene insertion 13, Eliezer Masliah
MGI ID: MGI:5774860
Synonyms: 3R Tau
Transgene: Tg(Thy1-MAPT*L266V*G272V)13Ema  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT*L266V*G272V)13Ema expresses 1 gene
 
Mutation detailsThe human Tau containing three ~32 amino acid repeats bearing the L266V and G272V mutations associated with familial forms of Picks Disease is under the control of the neuronal mouse Thy1 promoter. Line 13 is a high expressing line and expresses 8 fold higher levels than line 2. (J:229181)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:229181 Rockenstein E, et al., A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015;10(3):e0121570
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory