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Tg(Ckm-DNAJB6_ib*F93L)#Ccwe
Transgene Detail
Nomenclature
Symbol: Tg(Ckm-DNAJB6_ib*F93L)#Ccwe
Name: transgene insertion, Conrad C Weihl
MGI ID: MGI:5767288
Synonyms: hDNAJB6a-F93L
Transgene: Tg(Ckm-DNAJB6_ib*F93L)#Ccwe  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-DNAJB6_ib*F93L)#Ccwe expresses 1 gene
 
Mutation detailsThe human wild-type DNAJB6 isoform b with the most common Limb-girdle muscular dystrophy type 1D mutation, F93L, and with N-terminal V5 tags is under the control of the muscle-specific muscle creatine kinase promoter. Immunoblot analysis confirmed expression exclusively in skeletal muscle and not in heart, liver, kidney, or brain. Three lines were generated, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:226488)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:226488 Bengoechea R, et al., Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D. Hum Mol Genet. 2015 Dec 1;24(23):6588-602
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/09/2018
MGI 6.11
The Jackson Laboratory