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Psl6C57BL/6
QTL Variant Detail
Summary
QTL variant: Psl6C57BL/6
Name: promotion susceptibility QTL 6; C57BL/6
MGI ID: MGI:5767240
QTL: Psl6  Location: Chr9:65041191-95522808 bp  Genetic Position: Chr9, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:166052

Mapping of tumor promotion susceptibility was studied in congenic mouse strains to identify QTL segregating the phenotype. C57BL/6 Psl1ADBA and three subcongenic strains were informative in mapping Psl5(Psl1.1) to a region of mouse Chromsoome 9 between D9Mit112 and D9Mit200 and Psl6 (Psl1.2) between D9Mit316 and D9Mit76. Authors suggest Gsta4 as a candidate gene for Psl6.

References
Original:  J:166052 Abel EL, et al., Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. J Natl Cancer Inst. 2010 Nov 3;102(21):1663-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory