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Mef2dtm1.2Tfur
Targeted Allele Detail
Nomenclature
Symbol: Mef2dtm1.2Tfur
Name: myocyte enhancer factor 2D; targeted mutation 1.2, Takahisa Furukawa
MGI ID: MGI:5767098
Synonyms: Mef2d-
Gene: Mef2d  Location: Chr3:88142372-88172086 bp, + strand  Genetic Position: Chr3, 38.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:230346
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2 through 4 floxed. RT-PCR analysis confirmed the absence of transcript in the retina of homozygous mutant mice. (J:230346)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mef2d Mutation:  49 strains or lines available
References
Original:  J:230346 Omori Y, et al., Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory