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Mfsd14atm1Coll
Targeted Allele Detail
Summary
Symbol: Mfsd14atm1Coll
Name: major facilitator superfamily domain containing 14A; targeted mutation 1, William Colledge
MGI ID: MGI:5763015
Gene: Mfsd14a  Location: Chr3:116424813-116456264 bp, - strand  Genetic Position: Chr3, 50.42 cM, cytoband G2
Alliance: Mfsd14atm1Coll page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:230570
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ reporter gene and neomycin resistance cassette replaced 70 bp in exon 4. The deletion results in a frame shift and premature termination at glycine 93. RT-PCR confirmed the absence of wild-type transcript. (J:230570)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mfsd14a Mutation:  83 strains or lines available
References
Original:  J:230570 Doran J, et al., Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice. Reproduction. 2016 Jul;152(1):91-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory