Sik2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Sik2^tm1Lex
• Name: salt inducible kinase 2; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5762866
• Gene: Sik2 Location: Chr9:50804101-50920373 bp, - strand Genetic Position: Chr9, 27.75 cM
• Alliance: Sik2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo fusion cassette replaces exons 2 and 3. Quantitative PCR and Western blot analysis indicates more than 90% depletion in most tissues. (J:229999)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik2 Mutation: 43 strains or lines available

References

• Original: J:229999 Park J, et al., SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo. Diabetes. 2014 Nov;63(11):3659-73
• All: 2 reference(s)