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Emilin2tm1.2Jhp
Targeted Allele Detail
Nomenclature
Symbol: Emilin2tm1.2Jhp
Name: elastin microfibril interfacer 2; targeted mutation 1.2, Jane Hoover-Plow
MGI ID: MGI:5755385
Synonyms: E2-
Gene: Emilin2  Location: Chr17:71252172-71311556 bp, - strand  Genetic Position: Chr17, 41.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226863
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in the blood. (J:226863)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Emilin2 Mutation:  35 strains or lines available
References
Original:  J:226863 Huang M, et al., EMILIN2 regulates platelet activation, thrombus formation, and clot retraction. PLoS One. 2015;10(2):e0115284
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory