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Htra2tm1.1Hohj
Targeted Allele Detail
Nomenclature
Symbol: Htra2tm1.1Hohj
Name: HtrA serine peptidase 2; targeted mutation 1.1, Josephine Hoh
MGI ID: MGI:5752861
Synonyms: Htra2flox
Gene: Htra2  Location: Chr6:83051266-83054571 bp, - strand  Genetic Position: Chr6, 35.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225666
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 2 through 4 floxed. (J:225666)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htra2 Mutation:  5 strains or lines available
References
Original:  J:225666 Patterson VL, et al., Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. PLoS One. 2014;9(12):e115789
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory