Scyl2^tm1.2Spel
Targeted Allele Detail

Summary

• Symbol: Scyl2^tm1.2Spel
• Name: SCY1-like 2 (S. cerevisiae); targeted mutation 1.2, Stephane Pelletier
• MGI ID: MGI:5752502
• Gene: Scyl2 Location: Chr10:89474583-89522147 bp, - strand Genetic Position: Chr10, 45.05 cM
• Alliance: Scyl2^tm1.2Spel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225808
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette. Cre recombination removed exons 4 through 8. Western blot analysis confirmed the absence of protein expression in the cerebrum. (J:225808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scyl2 Mutation: 37 strains or lines available

References

• Original: J:225808 Gingras S, et al., SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22
• All: 1 reference(s)