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Ildr1tm1.1Lwa
Targeted Allele Detail
Nomenclature
Symbol: Ildr1tm1.1Lwa
Name: immunoglobulin-like domain containing receptor 1; targeted mutation 1.1, Lei Wang
MGI ID: MGI:5752280
Synonyms: Ildr1-
Gene: Ildr1  Location: Chr16:36693978-36726804 bp, + strand  Genetic Position: Chr16, 25.88 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221594
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct consisting of an FRT site, splice acceptor site, IRES, LacZ gene, loxP site neo cassette, FRT site and loxP site was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exons 2 and 3. LacZ expression was detected in the organ of Corti. qRT-PCR analysis confirmed the absence of mRNA expression in homozygous mutant mice. (J:221594)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ildr1 Mutation:  20 strains or lines available
References
Original:  J:221594 Sang Q, et al., ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42. Biol Open. 2015 Mar 27;4(4):411-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory