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Slc1a2tm1.1Pros
Targeted Allele Detail
Nomenclature
Symbol: Slc1a2tm1.1Pros
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2; targeted mutation 1.1, Paul A Rosenberg
MGI ID: MGI:5752263
Synonyms: GLT-1flox
Gene: Slc1a2  Location: Chr2:102658659-102790784 bp, + strand  Genetic Position: Chr2, 54.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221590
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted 217 bp (2:102739471) upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted 419 bp (2:102740358-102740394) downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 4 floxed. (J:221590)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a2 Mutation:  18 strains or lines available
References
Original:  J:221590 Petr GT, et al., Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015 Apr 1;35(13):5187-201
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory