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Ifngtm1.1Hayg
Targeted Allele Detail
Nomenclature
Symbol: Ifngtm1.1Hayg
Name: interferon gamma; targeted mutation 1.1, Howard A Young
MGI ID: MGI:5751448
Synonyms: ARE-del
Gene: Ifng  Location: Chr10:118441046-118445892 bp, + strand  Genetic Position: Chr10, 66.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220784
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced 162 nt of the adenylate-uridylate rich element (ARE) sequence. Cre-mediated recombination removed the selection cassette. Deletion of the ARE increases the half-life of the mRNA and results in constitutive expression of a low level of IFN-gamma under normal physiologic conditions. (J:220784)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ifng Mutation:  36 strains or lines available
References
Original:  J:220784 Lin FC, et al., IFN-gamma causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation. Blood. 2014 Dec 11;124(25):3699-708
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory