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Tlr5tm1.1Gewr
Targeted Allele Detail
Nomenclature
Symbol: Tlr5tm1.1Gewr
Name: toll-like receptor 5; targeted mutation 1.1, Andrew Gewirtz
MGI ID: MGI:5750875
Synonyms: Tlr5flox
Gene: Tlr5  Location: Chr1:182782353-182804010 bp, + strand  Genetic Position: Chr1, 86.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229155
Parent Cell Line:  iTL IC1 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to place a loxP site upstream of exon 4, and a frt::loxP::Neo::frt::loxP cassette inserted 211 base pairs downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. (J:229155)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr5 Mutation:  42 strains or lines available
References
Original:  J:229155 Chassaing B, et al., Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology. 2014 Dec;147(6):1363-77.e17
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory