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Npr1tm1.1Kkan
Targeted Allele Detail
Nomenclature
Symbol: Npr1tm1.1Kkan
Name: natriuretic peptide receptor 1; targeted mutation 1.1, Kenji Kangawa
MGI ID: MGI:5750455
Synonyms: GC-Aflox
Gene: Npr1  Location: Chr3:90450591-90465866 bp, - strand  Genetic Position: Chr3, 39.23 cM
Npr1tm1.1Kkan/Npr1tm1.1Kkan Tg(Tek-cre)1Ywa/0 mice injected with B16/F10 cells show increased number of plumonary and cardiac metastases

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220676
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site and FRT flanked neo cassette were inserted upstream of exon 1 and a loxP site was inserted downstream of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220676)
Generation of the Npr1tm1.1Kkan allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:  26 strains or lines available
References
Original:  J:220676 Nojiri T, et al., Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4086-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory