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Targeted Allele Detail
Symbol: Loxl2tm1.2Acan
Name: lysyl oxidase-like 2; targeted mutation 1.2, Amparo Cano
MGI ID: MGI:5750228
Synonyms: L2-
Gene: Loxl2  Location: Chr14:69609068-69695834 bp, + strand  Genetic Position: Chr14, 36.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:220689
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination deleted exon 2. Semi-quantitative PCR and Western blot analysis of whole-cell extracts and conditioned medium confirmed the absence of transcript and protein expression in MEFs derived from homozygous mutant mice. (J:220689)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Loxl2 Mutation:  5 strains or lines available
Original:  J:220689 Martin A, et al., Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. EMBO J. 2015 Apr 15;34(8):1090-109
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory