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Targeted Allele Detail
Symbol: Cntnap2tm2Pele
Name: contactin associated protein-like 2; targeted mutation 2, Elior Peles
MGI ID: MGI:5750095
Synonyms: Caspr2-lacZ, Cntnap2tlacz
Gene: Cntnap2  Location: Chr6:45036995-47278330 bp, + strand  Genetic Position: Chr6, 21.81 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:229005
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exon 1 (encoding the ATG and signal sequence) of the contactin associated protein-like 2 (Cntnap2) gene with a tau-LacZ gene and a neomycin resistance (neo) cassette in reverse orientation to the gene. Western blot and immunoblot analysis of brain and sciatic nerves, respectively, confirmed that no protein was expressed in mutant mice. (J:229005)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 230 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cntnap2 Mutation:  66 strains or lines available
Original:  J:229005 Gordon A, et al., Expression of Cntnap2 (Caspr2) in multiple levels of sensory systems. Mol Cell Neurosci. 2016 Jan;70:42-53
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory