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Tg(Camk2a-MAPT)601Ymot
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-MAPT)601Ymot
Name: transgene insertion 601, Yumiko Motoi
MGI ID: MGI:5749788
Synonyms: Tg601
Transgene: Tg(Camk2a-MAPT)601Ymot  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Camk2a-MAPT)601Ymot expresses 1 gene
 
Mutation detailsAn 8.5 kb portion of the calcium/calmodulin-dependent protein kinase II-alpha promoter containing upstream control regions and the transcriptional initiation site drives the expression of a human wild-type tau cDNA in forebrain neurons. Western blot confirmed expression in the brain and that tau becomes hyperphosphorylated with increasing age. (J:172762)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:172762 Kambe T, et al., Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiol Dis. 2011 Jun;42(3):404-14
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory