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Tg(Prnp-MAPT*K274Q*K281Q)286Lgn
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn
Name: transgene insertion 286, Li Gan
MGI ID: MGI:5708388
Synonyms: tauKQhigh, Tg(Prnp-MAPT*K274/281Q)2
Transgene: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Tg(Prnp-MAPT*K274Q*K281Q)286Lgn expresses 1 gene
 
Mutation detailsThe transgenic construct contains a mutant human MAPT (tauKQ) transgene with lysine-to-glutamine amino acid substitutions that recapitulate MAPT K274 and K281 acetylation under the control of the mouse prion protein, Prnp, gene promoter. The nucleotide substitutions are, respectively, A to C at position 820 and A to C at position 841. Founder line 286 has higher expression of the transgene than founder line 1. The transgene is expressed in hippocampus, cortex and cerebellum. (J:230252)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:230252 Tracy TE, et al., Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Apr 20;90(2):245-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory