About   Help   FAQ
Transgene Detail
Symbol: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn
Name: transgene insertion 286, Li Gan
MGI ID: MGI:5708388
Synonyms: tauKQhigh, Tg(Prnp-MAPT*K274/281Q)2
Transgene: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
Tg(Prnp-MAPT*K274Q*K281Q)286Lgn expresses 1 gene
Mutation detailsThe transgenic construct contains a mutant human MAPT (tauKQ) transgene with lysine-to-glutamine amino acid substitutions that recapitulate MAPT K274 and K281 acetylation under the control of the mouse prion protein, Prnp, gene promoter. The nucleotide substitutions are, respectively, A to C at position 820 and A to C at position 841. Founder line 286 has higher expression of the transgene than founder line 1. The transgene is expressed in hippocampus, cortex and cerebellum. (J:230252)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:230252 Tracy TE, et al., Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Apr 20;90(2):245-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory