Tg(Prnp-MAPT*K274Q*K281Q)286Lgn
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn
• Name: transgene insertion 286, Li Gan
• MGI ID: MGI:5708388
• Synonyms: tauKQ^high, Tg(Prnp-MAPT*K274/281Q)2
• Transgene: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn Location: unknown
• Alliance: Tg(Prnp-MAPT*K274Q*K281Q)286Lgn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Prnp-MAPT*K274Q*K281Q)286Lgn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  contains a K274Q and K281Q substitution (high expressor)

• Mutation details: The transgenic construct contains a mutant human MAPT (tauKQ) transgene with lysine-to-glutamine amino acid substitutions that recapitulate MAPT K274 and K281 acetylation under the control of the mouse prion protein, Prnp, gene promoter. The nucleotide substitutions are, respectively, A to C at position 820 and A to C at position 841. Founder line 286 has higher expression of the transgene than founder line 1. The transgene is expressed in hippocampus, cortex and cerebellum. (J:230252)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:230252 Tracy TE, et al., Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Apr 20;90(2):245-60
• All: 2 reference(s)