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Zfyve26tm1.1Cahb
Targeted Allele Detail
Nomenclature
Symbol: Zfyve26tm1.1Cahb
Name: zinc finger, FYVE domain containing 26; targeted mutation 1.1, Christian A Hubner
MGI ID: MGI:5707975
Gene: Zfyve26  Location: Chr12:79232346-79296304 bp, - strand  Genetic Position: Chr12, 35.51 cM
Abnormal gait of a Zfyve26tm1.1Cahb/Zfyve26tm1.1Cahb mouse walking on a beam

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223127
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette (Neo) flanked by frt sites and a loxP-site was inserted into intron 15. A second loxP-site together with a BamHI site was introduced into intron 14. Cre-mediated recombination removed exon 15 and the selection cassette. Northern blot analysis of total brain RNA from control and homozygous mutant animals showed that no expressed transcript is detectable. Western blot analysis with affinity purified antibodies against the N- terminus or the C-terminus of the encoded protein detected a polypeptide in brain extracts from wild-type but not from homozygous mutant mice. (J:223127)
Generation of the Zfyve26tm1.1Cahb allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfyve26 Mutation:  5 strains or lines available
References
Original:  J:223127 Khundadze M, et al., A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. PLoS Genet. 2013;9(12):e1003988
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/02/2021
MGI 6.16
The Jackson Laboratory