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Plp2tm1Dva
Targeted Allele Detail
Nomenclature
Symbol: Plp2tm1Dva
Name: proteolipid protein 2; targeted mutation 1, David Valle
MGI ID: MGI:5707490
Synonyms: Plp2-
Gene: Plp2  Location: ChrX:7667941-7671390 bp, - strand  Genetic Position: ChrX, 3.45 cM, cytoband A2-A3.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA LacZ-neo cassette was inserted into exon 1, six codons downstream of the translational start site. Northern blot analysis revealed absence of transcript in primary neurons isolated from hemizygous mutant males. Western blot analysis confirmed the absence of protein expression in mutant retinal tissue. (J:227053)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp2 Mutation:  9 strains or lines available
References
Original:  J:227053 Zhang L, et al., Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury. Hum Mol Genet. 2015 Dec 20;24(25):7221-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory