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Chrnb2tm1.1Cont
Targeted Allele Detail
Nomenclature
Symbol: Chrnb2tm1.1Cont
Name: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); targeted mutation 1.1, Anis Contractor
MGI ID: MGI:5707003
Synonyms: beta2V287L
Gene: Chrnb2  Location: Chr3:89753448-89764632 bp, - strand  Genetic Position: Chr3, 39.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228269
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 3 was replaced with one in which a point mutation results in the amino acid substitution of leucine for valine at position 287 (V287L). Cre-mediated recombination removed the floxed neomycin selection inserted downstream of the modified exon. (J:228269)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrnb2 Mutation:  4 strains or lines available
References
Original:  J:228269 Xu J, et al., Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the beta2 nicotinic receptor. Mol Psychiatry. 2011 Oct;16(10):1048-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory