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Dusp5tm1.1Skey
Targeted Allele Detail
Nomenclature
Symbol: Dusp5tm1.1Skey
Name: dual specificity phosphatase 5; targeted mutation 1.1, Stephen M Keyse
MGI ID: MGI:5706846
Gene: Dusp5  Location: Chr19:53529145-53541809 bp, + strand  Genetic Position: Chr19, 47.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216939
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and FRT flanked pgk-neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. (J:216939)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dusp5 Mutation:  6 strains or lines available
References
Original:  J:216939 Rushworth LK, et al., Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory