Tg(hs953-cre/ERT2,-GFP)526Jlr
Transgene Detail

Summary

• Symbol: Tg(hs953-cre/ERT2,-GFP)526Jlr
• Name: transgene insertion 526, John Rubenstein
• MGI ID: MGI:5705353
• Synonyms: 953-CreER-IRES-GFP
• Transgene: Tg(hs953-cre/ERT2,-GFP)526Jlr Location: unknown
• Alliance: Tg(hs953-cre/ERT2,-GFP)526Jlr page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(hs953-cre/ERT2,-GFP)526Jlr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  human	hs953

• Mutation details: This transgene contains the human enhancer element hs953, which is flanked on human Chr 2 by the Sp9 transcription factor (SP9) and corepressor interacting with RBPJ, 1 (CIR1) genes, followed by a minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:94077)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	hs953 (human) Summary of all recombinase alleles driven by hs953.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 2 reference(s)