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Targeted Allele Detail
Symbol: Alktm2.1Ics
Name: anaplastic lymphoma kinase; targeted mutation 2.1, Mouse Clinical Institute
MGI ID: MGI:5705326
Synonyms: AlkF1178L
Gene: Alk  Location: Chr17:71868972-72604627 bp, - strand  Genetic Position: Chr17, 43.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:228124
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
Mutation detailsExon 23 was replaced with one in which a point mutation (TTC to CTC) that results in the amino acid substitution of leucine for phenyalanine at position 1178. This mutation corresponds to the F1174 identified in patients with neuroblastoma. Cre-mediated recombination removed the neomycin resistance cassette inserted downstream of the modified exon. (J:228124)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alk Mutation:  43 strains or lines available
Original:  J:228124 Cazes A, et al., Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma. Oncotarget. 2014 May 15;5(9):2688-702
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory