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Targeted Allele Detail
Symbol: Irs4tm1.1Mfw
Name: insulin receptor substrate 4; targeted mutation 1.1, Morris F White
MGI ID: MGI:5705105
Gene: Irs4  Location: ChrX:141710998-141725217 bp, - strand  Genetic Position: ChrX, 62.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:221293
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin resistance cassette was inserted upstream of the coding sequence. An additional loxP site was inserted downstream of the coding sequence. Cre-mediated recombination removed the selection cassette and coding sequence. (J:221293)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs4 Mutation:  6 strains or lines available
Original:  J:221293 Sadagurski M, et al., Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol Metab. 2014 Feb;3(1):55-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory