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Ap1m2tm1.1Ohno
Targeted Allele Detail
Nomenclature
Symbol: Ap1m2tm1.1Ohno
Name: adaptor protein complex AP-1, mu 2 subunit; targeted mutation 1.1, Hiroshi Ohno
MGI ID: MGI:5704433
Synonyms: Ap1m2-, deltaEX4,5
Gene: Ap1m2  Location: Chr9:21294615-21312349 bp, - strand  Genetic Position: Chr9, 7.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226582
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA single loxP site was inserted upstream of exon 4 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 5. Cre-mediated recombination resulted in the deletion of the loxP-flanked exons 4 and 5 as well as the neomycin selection cassette. RT-PCR analysis demonstrated that no detectable transcript was present in the small intestinal epithelium of homozygous mutant mice. (J:226582)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ap1m2 Mutation:  16 strains or lines available
References
Original:  J:226582 Hase K, et al., AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Gastroenterology. 2013 Sep;145(3):625-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory