Madd^tm1Bpra
Targeted Allele Detail

Summary

• Symbol: Madd^tm1Bpra
• Name: MAP-kinase activating death domain; targeted mutation 1, Bellur S Prabhakar
• MGI ID: MGI:5704429
• Synonyms: KMA1^flox
• Gene: Madd Location: Chr2:90967705-91013404 bp, - strand Genetic Position: Chr2, 50.46 cM
• Alliance: Madd^tm1Bpra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225256
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. (J:225256)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Madd Mutation: 89 strains or lines available

References

• Original: J:225256 Li LC, et al., IG20/MADD plays a critical role in glucose-induced insulin secretion. Diabetes. 2014 May;63(5):1612-23
• All: 1 reference(s)