Del(4Cyp2j13-Cyp2j5)1Brs
Targeted Allele Detail

Summary

• Symbol: Del(4Cyp2j13-Cyp2j5)1Brs
• Name: deletion, Chr 4, Brian Seed 1
• MGI ID: MGI:5704342
• Synonyms: Cyp2j^-, Del1Brs, Del(4Cyp2j)1Brs
• Gene: Del(4Cyp2j13-Cyp2j5)1Brs Location: unknown Genetic Position: Chr4, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223128
• Parent Cell Line: J-A18 (B6-albino) (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion, Intragenic deletion Del(4Cyp2j13-Cyp2j5)1Brs involves 9 genes/genome features (2900072D07Rik, Cyp2j13, Cyp2j12 ...) View all Mutation details: TP901 integrase-mediated recombination of an attP3 site followed by a neomycin resistance gene and attP2 site introduced downstream of Cyp2j13 and an attP3 site followed by an ampicillin resistance gene, blasticidin resistance gene and attP2 site inserted upstream of Cyp2j5 deleted the intervening sequence. The neomycin, ampicillin and blasticidin resistance cassettes remain. (J:223128)

Construction of the Del(4Cyp2j13-Cyp2j5)1Brs deletion

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(4Cyp2j13-Cyp2j5)1Brs Mutation: 0 strains or lines available

References

• Original: J:223128 Zhou GL, et al., Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia. PLoS Genet. 2013 Nov;9(11):e1003950
• All: 2 reference(s)