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Targeted Allele Detail
Symbol: Bmp10tm1.1(Gdf2)Minh
Name: bone morphogenetic protein 10; targeted mutation 1.1, Minhong Yan
MGI ID: MGI:5703977
Synonyms: Bmp109
Gene: Bmp10  Location: Chr6:87428994-87434512 bp, + strand  Genetic Position: Chr6, 37.96 cM, cytoband D2
Germline Transmission:  Earliest citation of germline transmission: J:222016
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Bmp10tm1.1(Gdf2)Minh expresses 1 gene
Mutation detailsExons 1 and 2 were replaced with the corresponding sequence from Gdf2. A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. (J:222016)
Generation of the Bmp10tm1.1(Gdf2)Minh allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp10 Mutation:  6 strains or lines available
Original:  J:222016 Chen H, et al., Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11887-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory