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Gdf2tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Gdf2tm1Lex
Name: growth differentiation factor 2; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:5703975
Synonyms: Bmp9-, BMP9 KO
Gene: Gdf2  Location: Chr14:33941039-33947198 bp, + strand  Genetic Position: Chr14, 20.8 cM
Neutralization of BMP10 causes defective vascular development in Gdf2tm1Lex/Gdf2+ and Gdf2tm1Lex/Gdf2tm1Lex mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222016
Parent Cell Line:  Lex-2 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
    A beta-geo and puromycin resistance cassette replaced exon 2, encoding the receptor binding domain. (J:222016)
Generation of the Gdf2tm1Lex allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gdf2 Mutation:  19 strains or lines available
References
Original:  J:222016 Chen H, et al., Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11887-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory