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Cxxc5tm1Kych
Targeted Allele Detail
Summary
Symbol: Cxxc5tm1Kych
Name: CXXC finger 5; targeted mutation 1, Kang-Yell Choi
MGI ID: MGI:5703924
Gene: Cxxc5  Location: Chr18:35962450-35994741 bp, + strand  Genetic Position: Chr18, 19.26 cM, cytoband B3
Alliance: Cxxc5tm1Kych page
High bone mass phenotype in Cxxc5tm1Kych/Cxxc5tm1Kych mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226604
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2 which contains the ATG start codon. Immunohistochemistry confirmed the absence of protein expression in adult homozygous mutant tissues, including kidney tissue. (J:226362, J:226604)
Generation of the Cxxc5tm1Kych allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxxc5 Mutation:  50 strains or lines available
References
Original:  J:226604 Kim HY, et al., CXXC5 is a negative-feedback regulator of the Wnt/beta-catenin pathway involved in osteoblast differentiation. Cell Death Differ. 2015 Jun;22(6):912-20
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory