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Ctsdtm1.1Thre
Targeted Allele Detail
Nomenclature
Symbol: Ctsdtm1.1Thre
Name: cathepsin D; targeted mutation 1.1, Thomas Reinheckel
MGI ID: MGI:5702318
Synonyms: Ctsdflox
Gene: Ctsd  Location: Chr7:142375916-142387870 bp, - strand  Genetic Position: Chr7, 87.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227618
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a loxP-flanked exon 2 of and an FRT-flanked puromycin selection cassette was intregrated into the locus by homologous recombination. Subsequently, the selection cassette was removed by flpe recombination. (J:227618)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsd Mutation:  9 strains or lines available
References
Original:  J:227618 Ketscher A, et al., Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10. Biochimie. 2016 Mar;122:219-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory