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Pvalbtm2(cre/ERT2)Zjh
Targeted Allele Detail
Nomenclature
Symbol: Pvalbtm2(cre/ERT2)Zjh
Name: parvalbumin; targeted mutation 2, Z Josh Huang
MGI ID: MGI:5700403
Synonyms: PV-2A-CreEr, PV-CreER
Gene: Pvalb  Location: Chr15:78191114-78206400 bp, - strand  Genetic Position: Chr15, 36.93 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235123
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), followed by a frt-flanked neo cassette, upstream of the stop codon. (J:235123)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pvalb     Summary of all recombinase alleles driven by Pvalb. Comparative matrix view of recombinase activities
User Notes:
 Additional information submitted by the research community
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pvalb Mutation:  24 strains or lines available
References
Original:  J:235123 He M, et al., Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016 Sep 21;91(6):1228-1243
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory