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Viptm2.1(flpo)Zjh
Targeted Allele Detail
Nomenclature
Symbol: Viptm2.1(flpo)Zjh
Name: vasoactive intestinal polypeptide; targeted mutation 2.1, Z Josh Huang
MGI ID: MGI:5700390
Synonyms: VIP-Flp, VIP-ires-Flpo
Gene: Vip  Location: Chr10:5589218-5597617 bp, + strand  Genetic Position: Chr10, 1.97 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235123
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe targeting vector is designed to insert an internal ribosome entry site (IRES) fused to flpo recombinase gene (a codon-optimized flpe gene modified for translation in mammalian cells and higher recombination efficiency in cells and in mice), followed by a loxP-flanked neo cassette, downstream of the stop codon of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:235123)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Vip     Summary of all recombinase alleles driven by Vip. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vip Mutation:  19 strains or lines available
References
Original:  J:235123 He M, et al., Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016 Sep 21;91(6):1228-1243
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory