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Tg(Plp1-HTT*150Q)4aXjl
Transgene Detail
Nomenclature
Symbol: Tg(Plp1-HTT*150Q)4aXjl
Name: transgene insertion 4a, Xiao-Jiang Li
MGI ID: MGI:5700344
Synonyms: PLP-150Q
Transgene: Tg(Plp1-HTT*150Q)4aXjl  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Plp1-HTT*150Q)4aXjl expresses 1 gene
 
Mutation detailsExpression of a cDNA encoding N-terminal human HTT (amino acids 1-212) containing 150 glutamines in the repeat region (150Q) is under the control of the oligodendrocyte specific murine Plp1 promoter. Western blot confirmed formation of aggregated HTT in the brain and selective expression in the brain stem, striatum, and corpus callosum. (J:221608)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:221608 Huang B, et al., Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 2015 Mar 18;85(6):1212-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory