Pde6g^{tm1(cre/ERT2)Eye}
Targeted Allele Detail

Summary

• Symbol: Pde6g^{tm1(cre/ERT2)Eye}
• Name: phosphodiesterase 6G, cGMP-specific, rod, gamma; targeted mutation 1, Stephen H Tsang
• MGI ID: MGI:5696992
• Synonyms: Pde6g^CreERT2
• Gene: Pde6g Location: Chr11:120338433-120344326 bp, - strand Genetic Position: Chr11, 84.14 cM
• Alliance: Pde6g^{tm1(cre/ERT2)Eye} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226244
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pde6g^{tm1(cre/ERT2)Eye} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pde6g (MGI:97526)

• An inducible cre recombinase gene (cre/ERT2) and neomycin resistance cassette replaced exon 2 and 3. (J:226244)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pde6g (mouse) Summary of all recombinase alleles driven by Pde6g. Comparative matrix view of recombinase activities Alliance mouse Pde6g gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde6g Mutation: 11 strains or lines available

References

• Original: J:226244 Koch SF, et al., Halting progressive neurodegeneration in advanced retinitis pigmentosa. J Clin Invest. 2015 Sep;125(9):3704-13
• All: 8 reference(s)