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Tg(Prl-EGFR)#Sme
Transgene Detail
Summary
Symbol: Tg(Prl-EGFR)#Sme
Name: transgene insertion, Shlomo Melmed
MGI ID: MGI:5696741
Transgene: Tg(Prl-EGFR)#Sme  Location: unknown  
Alliance: Tg(Prl-EGFR)#Sme page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prl-EGFR)#Sme expresses 1 gene
 
Mutation detailsThe human EGFR and mCherry cDNAs are under the control of the rat Prl enhancer/promoter. Immunoblot analysis indicates an approximate 13-fold increase in EGFR levels in the pituitary compared with endogenous levels. mCherry fluorescence is not detected. (J:219654)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:219654 Liu X, et al., ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan;156(1):71-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory