Tg(Prl-EGFR)#Sme
Transgene Detail

Summary

• Symbol: Tg(Prl-EGFR)#Sme
• Name: transgene insertion, Shlomo Melmed
• MGI ID: MGI:5696741
• Transgene: Tg(Prl-EGFR)#Sme Location: unknown
• Alliance: Tg(Prl-EGFR)#Sme page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prl-EGFR)#Sme expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

• Mutation details: The human EGFR and mCherry cDNAs are under the control of the rat Prl enhancer/promoter. Immunoblot analysis indicates an approximate 13-fold increase in EGFR levels in the pituitary compared with endogenous levels. mCherry fluorescence is not detected. (J:219654)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:219654 Liu X, et al., ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan;156(1):71-9
• All: 1 reference(s)