Cdk12^tm1.1Mjfn
Targeted Allele Detail

Summary

• Symbol: Cdk12^tm1.1Mjfn
• Name: cyclin dependent kinase 12; targeted mutation 1.1, Ming-Ji Fann
• MGI ID: MGI:5695632
• Synonyms: Cdk12^f, Cdk12^fx
• Gene: Cdk12 Location: Chr11:98093885-98169330 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Cdk12^tm1.1Mjfn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217121
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:217121)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk12 Mutation: 75 strains or lines available

References

• Original: J:217121 Chen HR, et al., Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Exp Neurol. 2014 Nov;261:10-21
• All: 3 reference(s)