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Lmnatm1Rben
Targeted Allele Detail
Nomenclature
Symbol: Lmnatm1Rben
Name: lamin A; targeted mutation 1, Ricardo Benavente
MGI ID: MGI:5695312
Synonyms: Lamin C2-
Gene: Lmna  Location: Chr3:88481148-88509932 bp, - strand  Genetic Position: Chr3, 38.84 cM
Small testes and absence of post-meiotic cells in the Lmnatm1Rben/Lmnatm1Rben testes

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223056
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neomycin resistance cassette replaced exon 1a. Western blot analysis confirmed the absence of isoform C2 protein expression in the testes without affected expression of isoform A/C in the testes and liver. (J:223056)
Generation of the Lmnatm1Rben allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  59 strains or lines available
References
Original:  J:223056 Link J, et al., The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse. PLoS Genet. 2013;9(1):e1003261
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory