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Targeted Allele Detail
Symbol: Lmnatm1Rben
Name: lamin A; targeted mutation 1, Ricardo Benavente
MGI ID: MGI:5695312
Synonyms: Lamin C2-
Gene: Lmna  Location: Chr3:88480147-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Small testes and absence of post-meiotic cells in the Lmnatm1Rben/Lmnatm1Rben testes

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:223056
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked neomycin resistance cassette replaced exon 1a. Western blot analysis confirmed the absence of isoform C2 protein expression in the testes without affected expression of isoform A/C in the testes and liver. (J:223056)
Generation of the Lmnatm1Rben allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  67 strains or lines available
Original:  J:223056 Link J, et al., The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse. PLoS Genet. 2013;9(1):e1003261
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory