Rasgrp1^tm1.1Wz
Targeted Allele Detail

Summary

• Symbol: Rasgrp1^tm1.1Wz
• Name: RAS guanyl releasing protein 1; targeted mutation 1.1, Weiguo Zhang
• MGI ID: MGI:5694744
• Synonyms: RasGRP1^d
• Gene: Rasgrp1 Location: Chr2:117110464-117173358 bp, - strand Genetic Position: Chr2, 59.19 cM
• Alliance: Rasgrp1^tm1.1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Exon 15 was replaced with one in which a STOP codon was inserted to ensure retention of the C1 domain but deletion of the tail. A floxed neomycin resistance cassette was inserted into intron 15. Cre-mediated recombination removed the selection cassette. (J:225109)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgrp1 Mutation: 55 strains or lines available

References

• Original: J:225109 Fuller DM, et al., Regulation of RasGRP1 function in T cell development and activation by its unique tail domain. PLoS One. 2012;7(6):e38796
• All: 1 reference(s)